Precision Meets Innovation:
SPR Solutions for Every Stage of Drug Discovery
What is SPR?
Surface Plasmon Resonance (SPR) is a label-free, real-time biophysical technique used to study interactions between biological molecules. SPR measures changes in the refractive index near a sensor surface when molecules bind to it. This change is detected as a shift in the resonance angle of surface plasmons (electron oscillations on a metal surface). Unlike endpoint assays, SPR directly measures how two molecules bind and dissociate, providing detailed insight into the strength, stability, and quality of molecular interactions.
Figure courtesy of Marion J. Limo, ISAC, School of Pharmacy, University of Nottingham.
SPR workflow
Immobilization of Ligand
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Covalent coupling methods, such as amine coupling
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Non-covalent or affinity capture methods
Analyte introduction and Signal acquisition
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Injection of analyte over the immobilized ligand under controlled flow conditions.
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Recording of real-time interaction as a sensorgram, showing association and dissociation phases of binding
Surface Regeneration
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Regeneration of the sensor surface to remove residual analyte to enable multiple runs
Data Interpretation
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Fitting of experimental data to binding models.
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Determination of kinetic and affinity parameters: association rate constant (ka), dissociation rate constant (kd), and the equilibrium dissociation constant (KD)
Figure courtesy Cytiva insights
SPR Across Various Modalities
“ The Universal Language of Molecular Interactions"
Why Us: Our Edge - Value Proposition
Scientific Expertise
We leverage deep SPR expertise and a proven track record to deliver precise, real-time, label-free kinetic and affinity data.
Biology-First Integration
We integrate target biology insights with modality context to develop novel SPR-based solutions to target the "undruggable targets".
Modality-Agnostic Capability
Our SPR services support diverse therapeutic modalities, from small molecules and covalent binders to PROTACs, molecular glues, ADCs, biologics, and nucleic acid–binding agents, enabling consistent evaluation across programs.
Purpose-Built Innovation
Our team specializes in developing innovative, customized SPR assays to address project-specific complexities, ensuring data relevance, interpretability, and confidence in downstream decisions.
Our Service Offerings
We provide SPR solutions for every stage of drug discovery, including all chemical modalities like:
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Small molecules (Covalent/ Non-covalent) and Fragments
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Peptides
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PROTACs and Molecular Glues (MGs)
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Antibodies
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Antibody-drug conjugates (ADCs)
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RNA /DNA- binding molecules
SPR Solutions for Every Stage of Drug Discovery
From Question to Insight: Our SPR Framework
Consultation
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Understand client needs and program objectives
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Define the critical scientific question and program context
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Design the study and align on clear deliverables
Feasibility Assessment
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Assess target suitability and interaction viability
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Evaluate sample quality, stability, and experimental readiness
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Identify technical risks and assay compatibility early
Assay Development
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Select appropriate surface chemistry and immobilization strategy
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Optimize assay conditions for biological relevance and stability
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Validate assay performance and reproducibility
Data Acquisition
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Execute experiments under well-controlled, consistent conditions
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Generate high-quality, real-time interaction data
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Monitor signal integrity and experimental performance
Data Evaluation & Insights
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Process and fit data using appropriate binding models
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Distinguish true interactions from artefacts or noise
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Evaluate confidence, limitations, and data robustness
Insight Delivery
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Summarize key findings with clarity and context
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Document assumptions, limitations, and confidence levels
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Provide actionable insights to guide next steps
Contact Our Experts
Dr. Megha Goyal
Founder I Director
Email:
Abhinavayan’s SPR services are driven by scientific context, not just instrumentation. We bring target insight, assay strategy, and advanced SPR execution together to deliver binding data that meaningfully guides precision drug discovery.